The Sex-lethal gene of drosophila: DNA alterations associated with sex-specific lethal mutations
نویسندگان
چکیده
منابع مشابه
A female-specific lethal lesion in an X-linked positive regulator of the Drosophila sex determination gene, Sex-lethal.
Characterization of a partial-loss-of-function, female-specific lethal mutation has identified an X-linked genetic element (1-34.3; 10B4) that functions as a positive regulator of Sxl, a central gene controlling sex determination in Drosophila melanogaster. The name, sisterless-a, was chosen both to suggest functional similarities that exist between this gene and another positive regulator of S...
متن کاملEvolution of the Drosophila feminizing switch gene Sex-lethal.
In Drosophila melanogaster, the gene Sex-lethal (Sxl) controls all aspects of female development. Since melanogaster males lacking Sxl appear wild type, Sxl would seem to be functionally female specific. Nevertheless, in insects as diverse as honeybees and houseflies, Sxl seems not to determine sex or to be functionally female specific. Here we describe three lines of work that address the ques...
متن کاملThe Drosophila splicing regulator sex-lethal directly inhibits translation of male-specific-lethal 2 mRNA.
Male-specific expression of the protein male-specific-lethal 2 (MSL-2) controls dosage compensation in Drosophila. msl-2 gene expression is inhibited in females by Sex-lethal (SXL), an RNA binding protein known to regulate pre-mRNA splicing. An intron present at the 5' untranslated region (UTR) of msl-2 mRNA contains putative SXL binding sites and is retained in female flies. Here we show that ...
متن کاملSex-specific regulation of the male-specific lethal-1 dosage compensation gene in Drosophila.
Dosage compensation in Drosophila occurs by a twofold increase in transcription per copy of X-linked genes in males (XY) compared with females (XX). msl-1 is one of four genes that are essential for dosage compensation in males, and MSL-1 protein is associated specifically with the male X chromosome. To explore the basis for the sex specificity of dosage compensation, we examined MSL-1 expressi...
متن کاملMisregulation of sex-lethal and disruption of male-specific lethal complex localization in Drosophila species hybrids.
A major model system for the study of evolutionary divergence between closely related species has been the unisexual lethality resulting from reciprocal crosses of Drosophila melanogaster and D. simulans. Sex-lethal (Sxl), a critical gene for sex determination, is misregulated in these hybrids. In hybrid males from D. melanogaster mothers, there is an abnormal expression of Sxl and a failure of...
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ژورنال
عنوان ژورنال: Cell
سال: 1985
ISSN: 0092-8674
DOI: 10.1016/0092-8674(85)90181-3